TRANSLATIONAL PHYSIOLOGY Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism
نویسندگان
چکیده
Victoria Sid, Nan Wu, Lindsei K. Sarna, Yaw L. Siow, James D. House, and Karmin O St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada; Department of Physiology and Pathophysiology, Winnipeg, Manitoba, Canada; Department of Animal Science, University of Manitoba, Winnipeg, Manitoba, Canada; Agriculture and Agri-Food Canada, Winnipeg, Manitoba, Canada; and Department of Human Nutritional Science, University of Manitoba, Winnipeg, Manitoba, Canada
منابع مشابه
Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism.
AMPK is an endogenous energy sensor that regulates lipid and carbohydrate metabolism. Nonalcoholic fatty liver disease (NAFLD) is regarded as a hepatic manifestation of metabolic syndrome with impaired lipid and glucose metabolism and increased oxidative stress. Our recent study showed that folic acid supplementation attenuated hepatic oxidative stress and lipid accumulation in high-fat diet-fe...
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تاریخ انتشار 2015